Identificación de las proteínas fosfatasas responsables de la inactivación de las map quinasas en neuronas granulares de cerebelopapel de los receptores p2x7 y trks

  1. Queipo García, María José
Supervised by:
  1. María Teresa Miras Portugal Director
  2. Esmerilda García Delicado Director
  3. Raquel Pérez Sen Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 08 November 2019

Committee:
  1. Antonio Puyet Catalina Chair
  2. Eva de Lago Femia Secretary
  3. Javier Díaz Nido Committee member
  4. Paulo Correia-de-Sá Committee member
  5. Ana Isabel Rojo Sanchís Committee member
Department:
  1. Bioquímica y Biología Molecular

Type: Thesis

Teseo: 151091 DIALNET

Abstract

Purinergic neurotransmission in the cerebellum has been widely studied by our research group, being identified several signaling pathways activated by nucleotide receptors in cerebellar granule neurons and astrocytes (Espada et al., 2010; Carrasquero et al., 2009; Ortega et al., 2010; Ortega et al., 2011). In granule neurons, P2X7 ionotropic receptor and P2Y13 metabotropic receptor exert neuroprotective effects against several proapoptotic stimuli, activating different signalling pathways. These include the survival pathway leading to GSK3 (Glycogen synthase kinase 3) inhibition, either through the PI3K/Akt (Phosphoinositide 3-kinase/ Protein kinase B) canonical pathway for P2Y13 receptor, or through a protein kinase C-dependent pathway for the P2X7 receptor. In addition, both receptors activate the MAP Kinases, ERK1,2 (Extracellular signal–regulated kinases), through CaMKII (Calcium calmodulin kinase II) and PI3K/Akt for P2X7 and P2Y13 receptors, respectively (Ortega et al., 2008; Ortega et al., 2009; Ortega et al., 2011)...