Optimization of thrombolytic therapy in brain pathology

  1. Correa Paz, Clara
Supervised by:
  1. Francisco Campos Pérez Director
  2. Tomas Sobrino Moreiras Director
  3. José Antonio Castillo Sánchez Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 28 November 2019

Committee:
  1. Ignacio Lizasoain Hernández Chair
  2. Pablo Hervella Lorenzo Secretary
  3. Marina Rubio Gómez Committee member

Type: Thesis

Abstract

Ischemic stroke is the leading cause of disability in the developed countries. The only approved drug treatment is the recombinant tissue plasminogen activator (rtPA). However, its use is limited due to the short half-life side effects. In this study we have developed rtPA-loaded nanocapsules combined with ultrasound application, which we used as trigger to induce rtPA from our nanocapsules. These nanocapsules were also able to extend the half-life of rtPA after in vivo administration and reach the ischemic region. Overall, we have developed promising nanocapsules for the triggered release of rtPA in the brain with potential application in ischemic stroke.