Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study

  1. Julia Serrano 1
  2. Rosa Mª López-Pintor Muñoz 2
  3. Mónica Fernández Castro 3
  4. Lucía Ramírez Martínez Acitores 2
  5. Mariano Sanz Alonso 2
  6. Elisabeth Casañas Gil 2
  7. Jesús Alberto García 4
  8. Sheila Recuero 5
  9. Cristina Bohórquez Heras 6
  10. Gonzalo Hernández Vallejo 2
  1. 1 pHD student. Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain
  2. 2 Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain
  3. 3 Rheumatology Service, Hospital Puerta de Hierro, Madrid, Spain
  4. 4 Rheumatology Service, Hospital de la Princesa, Madrid, Spain
  5. 5 Rheumatology Service, Fundación Jiménez Díaz, Madrid, Spain
  6. 6 Rheumatology Service, Hospital Principie de Asturias, Alcalá de Henares, Madrid
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2020

Volumen: 25

Número: 1

Páginas: 17

Tipo: Artículo

DOI: 10.4317/MEDORAL.23254 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

To evaluate the presence of oral lesions in a group of patients with primary Sjögren’s syndrome (pSS) and compare these results with a matched control group (CG). An observational cross-sectional study was conducted. 61 pSS patients (60 women, 1 man, mean age 57.64±13.52) diagnosed according to the American European Criteria (2002), and 122 matched control patients (120 women, 2 men, mean age 60.02±13.13) were included. Demographic and medical data, oral lesions and salivary flow rate were collected. Compared with the controls, pSS patients were 3.95 more likely to have oral lesions (OR 3.95; 95% CI 2.06-7.58; p=0.0001). 57.4% pSS patients presented oral lesions compared to 25.4% in CG. The most common were candidiasis (13.1% vs 2.5%), traumatic lesions (13.1% vs 4.1%), apthae (8.2% vs 0), and fissuration of the tongue (8.2% vs 0.8%). pSS patients with oral lesions had lower salivary flow levels (stimulated and unstimulated), although these differences were not significant. Significant associations were found between the presence of oral lesions and systemic manifestations and history of parotid gland enlargement in pSS patients. pSS patients suffer more oral lesions than general population and these lesions may aggravate the pSS disease.

Referencias bibliográficas

  • Medeiros, CCG,Borges, LGDA,Cherubini, K,Salum, FG,Silva, RMD,de Figueiredo, MAZ. (2018). Oral yeast colonization in patients with primary and secondary Sjögren's syndrome. Oral Dis. 24. 1367
  • Baer, AN,Wallit, B. (2018). Update on Sjögren syndrome and other causes of sicca in older adults. Rheum Dis Clin North Am. 44. 419
  • Mavragani, CP,Moutsopoulos, HM. (2010). The geoepidemiology of Sjögren's syndrome. Autoimmun Rev. 95. 305
  • Tincani, A,Andreoli, L,Cavazzana, I,Doria, A,Favero, M,Fenini, MG. (2013). Novel aspects of Sjögren's syndrome in 2012. BMC Medicine. 11. 93
  • Billings, M,Amin Hadavand, M,Alevizos, I. (2017). Comparative analysis of the 2016 ACR- EULAR and the 2002 AECG classification criteria for Sjögren's syndrome: Findings from the NIH cohort. Oral Dis. 24. 184
  • Vitali, C,Bombardieri, S,Jonsson, R,Moutsopoulos H, M,Alexander, EL,Carsons, SE. (2002). European classification criteria for Sjögren's syndrome (SS). Classification criteria for Sjogren's syndrome: A revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 61. 554
  • Shiboski, CH,Shiboski, SC,Seror, R,Criswell, LA,Labetoulle, M,Lietman, TM. (2016). 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome. A consensus and data-driven methodology involving three international patient cohorts. ARD. 76. 9-16
  • Ship, JA,Fox, PC,Baum, BJ. (1991). How much saliva is enough? 'Normal' function defined. JADA. 122. 63
  • Márton, K,Boros, I,Varga, G,Zelles, T,Fejérdy, P,Zeher, M. (2006). Evaluation of palatal flow rate and oral manifestations in patients with Sjögren's syndrome. Oral Dis. 12. 480
  • Patinen, P,Aine, L,Collin, P,Hietanen, J,Korpela, M,Enckell, G. (2004). Oral findings in coeliac and Sjögren's syndrome. Oral Dis. 10. 330
  • Likar-Manookin, K,Stewart, C,Al-Hashimi, I,Curtis, W,Berg, K,Cherian, K. (2013). Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome. Oral Dis. 19. 598-603
  • Pedersen, AM,Reibel, J,Nordgarden, H,Bergem, HO,Jensen, JL,Nauntofte, B. (1999). Primary Sjögren's syndrome: salivary gland function and clinical oral findings. Oral Dis. 5. 128
  • Fernández Castro, M,et, al. (2019). Evaluación protocolizada odontológica en el paciente con síndrome de Sjögren primario. Proyecto EPOX-SSp: metodología y objetivos. Reumatol Clin.
  • Kramer, IR,Pindborg, JJ,Bezroukov, V,Infirri, JS. (1980). World Health Organization. Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. Comm Dent Oral Epidemiol. 8. 1-26
  • López-Pintor, RM,Hernández, G,de Arriba, L,de Andrés, A. (2010). Comparison of oral lesion prevalence in renal transplant patients under immunosuppressive therapy and healthy controls. Oral Dis. 16. 89-95
  • Blochowiak, K,Olewicz-Gawlik, A,Polanska, A,Nowak-Gabryel, M,Kocięcki, J,Witmanowski, H. (2016). Oral mucosal manifestations in primary and secondary Sjögren syndrome and dry mouth syndrome. Adv Dermatol Allergol. 33. 23
  • Torres, SR,Peixoto, CB,Caldas, DM,Silva, EB,Akiti, T,Nucci, M. (2002). Relationship between salivary flow rates and Candida counts in subjects with xerostomia. Oral Sur Oral Med Oral Pathol Oral Radiol. 93. 149
  • Hsu, S,Dickinson, D. (2006). A new approach to Managing Oral Manifestations of Sjögren's Syndrome and Skin Manifestations of Lupus. Biochem Mol Biol. 39. 229
  • Tapper-Jones, L,Aldred, M,Walker, DM. (1980). Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome. J Clin Pathol. 33. 282
  • Navazesh, M. (1993). Methods for collecting saliva. Ann N Y Acad Sci. 694. 72
  • Koseki, M,Maki, Y,Matsukubo, T,Ohashi, Y,Tsubota, K. (2004). Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes. Oral Dis. 10. 75-80
  • Olate, S,Muñoz, D,Neumann, S,Pozzer, L,Cavalieri-Pereira, L,de Moraes, M. (2014). A descriptive study of the oral status in subjects with Sjögren's syndrome. Int J Clin Exp Med. 7. 1140
  • Rhodus, NL,Bloomquist, C,Liljemark, W,Bereuter, J. (1997). Prevalence, density, and manifestations of oral Candida albicans in patients with Sjögren's syndrome. J Otolaryngol. 26. 300
  • Yan, Z,Young, LA,Hua, H,Xu, Y. (2011). Multiple Oral Candida Infections in Patients with Sjögren's syndrome- Prevalence and Clinical and Drug Susceptibility Profiles. J Rheum. 38. 2428
  • Lynge Pedersen, AM,Nauntofte, B,Smidt, D,Torpet, LA. (2015). Oral mucosal lesions in older people: relation to salivary secretion, systemic diseases and medications. Oral Dis. 21. 721
  • Bergdahl, M. (2000). Salivary flow and oral complaints in adult dental patient. Community Dentistry and Oral Epidemiology. 28. 59-66
  • Serrano, J,López-Pintor, RM,González-Serrano, J,Fernández-Castro, M,Casañas, E,Hernández, G. (2018). Oral lesions in Sjögren's syndrome: a systematic review. Med Oral Patol Oral Cir Bucal. 23. 391-400
  • Ergun, S,Cekici, A,Nursen Topcuoglu, N,Migliari, DA,Güven Külekçi, G,Tanyeri, H. (2010). Oral status and Candida colonization in patients with Sjögren's Syndrome. Med Oral Patol Oral Cir Bucal. 15. 310
  • Ferro, F,Vagelli, R,Bruni, C,Cafaro, G,Marcucci, E,Bartolini, E. (2016). One year in review 2016: Sjögren's syndrome. Clin Exp Rheumatol. 34. 161
Fuente de los datos: Dialnet