Efecto de la suplementación oral con una fórmula que contiene ácido R-lipoico en pacientes con glaucoma
- S.M. Sanz-González 1
- J. Raga-Cervera 12
- M. Aguirre Lipperheide 3
- V. Zanón-Moreno 168
- V. Chiner 4
- A.I. Ramírez 57
- M.D. Pinazo-Durán 16
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1
Generalitat Valenciana
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2
Hospital de Manises
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- 3 Nua Biological Innovations S.L., Erandio, Vizcaya, España
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Hospital Universitario Doctor Peset
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Instituto de Salud Carlos III
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Universitat de València
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Universidad Complutense de Madrid
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Universidad Internacional de Valencia
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ISSN: 0365-6691
Any de publicació: 2020
Volum: 95
Número: 3
Pàgines: 120-129
Tipus: Article
Altres publicacions en: Archivos de la Sociedad Española de Oftalmologia
Resum
Objective To analyse the safety and effectiveness of the oral administration of a commercialised supplement containing R-alpha lipoic acid, taurine, vitamins C and E, lutein, zeaxanthin, zinc, copper and docosahexaenoic acid, in patients with primary open angle glaucoma (POAG), and in control subjects. Material and methods A prospective study of cases and controls was carried out, including 30 participants of both genders that were divided into: POAG Group (n = 15) and a control group (CG; n = 15), assigned to the oral intake of NuaDHA preparations Vision® (1 pill/day) + NuaDHA 1000 (2 pills/day) for 6 months. Participants were interviewed, ophthalmologically examined, and peripheral blood was taken for routine analysis and the determination of the pro-oxidant (malondialdehyde) and total antioxidant status. Statistical analysis was performed using the SPSS 22.0 program. Results After 6 months of supplementation, there was a significant increase in the plasma total antioxidant status (1.073 ± 0.090 mM vs 1.276 ± 0.107 mM, P = .028), along with a parallel decrease in malondialdehyde (7.066 ± 1.070 μM vs 2.771 ± 0.462 μM, P = .005) in the POAG group. The malondialdehyde also decreased in the control group (6.17 ± 1.336 vs. 2.51 ± 0.391, P = .028). The Schirmer test improved (20-30%) and the subjective dry eye signs/symptoms noticeably decreased in the POAG group versus the CG. Conclusions Formulations containing antioxidant vitamins, R-alpha lipoic acid and docosahexaenoic acid, administered for 6 consecutive months, counteracted the oxidative stress by further stabilising the morphological/functional parameters of both the ocular surface and the glaucoma, without presenting with adverse effects or intolerances.