Papel del sistema renina-angiotensina en el embarazo y la preeclampsia

  1. N. Martell Claros 1
  2. J.E. Asenjo de la Fuente 2
  3. M. Abad Cardiel 1
  4. J.A. García Donaire 1
  5. M.A. Herráiz 3
  1. 1 Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, España
  2. 2 Unidad de Ecografía y Diagnóstico Prenatal, Instituto de Salud de la Mujer JBLL, Hospital Clínico San Carlos, Madrid, España
  3. 3 Instituto de Salud de la Mujer JBLL, Hospital Clínico San Carlos, Madrid, España
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Journal:
Hipertensión y riesgo vascular

ISSN: 1889-1837

Year of publication: 2020

Volume: 37

Issue: 2

Pages: 72-77

Type: Article

DOI: 10.1016/J.HIPERT.2020.02.003 DIALNET GOOGLE SCHOLAR

More publications in: Hipertensión y riesgo vascular

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Abstract

The renin-angiotensin system (ARS) is a hormonal cascade that regulates blood pressure, electrolytes and water balance. AngiotensinII (AII) exerts its effects through the AT1 and AT2 receptors. AT1 is found in the syncytiotrophoblast, AT2 predominates during foetal development and its stimulation inhibits cell growth, increases apoptosis, causes vasodilation and regulates the development of foetal tissue. There is also an SRA in the placenta. The local generation of AII is responsible for the activation of AT1 receptors in the trophoblast. In normal pregnancy, concomitantly with reduction of blood pressure the circulating RAS increases, but blood pressure does not rise due to AII refractoriness, which does not occur in preeclampsia. We review the role of the SRA in normal pregnancy and preeclampsia.

Data source: Dialnet