Smart drug delivery systems designed to improve inflammatory bowel disease therapy
- Hernández Teruel, Adrián
- Marta González Álvarez Director
- Virginia Merino Sanjuán Director
- Ramón Martínez Máñez Director
Universidade de defensa: Universitat Politècnica de València
Fecha de defensa: 20 de setembro de 2019
- Rosa María Hernández Martín Presidente/a
- Ana Isabel Torres Suárez Secretaria
- Paulo Jorge Pereira Alves Paixao Vogal
Tipo: Tese
Resumo
This PhD thesis entitled "Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy" is focused on the design, synthesis, characterization and in vivo evaluation of several Colon Drug Delivery Systems (CDDS) using hybrid mesoporous silica microparticles as scaffolds containing molecular gates. In conclusion, the studies shown in this Thesis demonstrate that mesoporous silica materials in combination with responsive molecular gates have great potential in the design and preparation of new CDDS to improve the therapeutic options available for IBD. The possibility to adapt the cargo and the molecular gate makes mesoporous silica support especially appealing for similar controlled drug delivery applications in the biomedical field. We hope that the obtained results could inspire the development of new innovative smart drug delivery systems in this or other fields.