Uso de biomateriales con fines neurorregenerativosaplicación en modelo experimental de traumatismo craneoencefálico
- J.M. Soria
- Carlos Martínez Ramos
- José Antonio Andrades Gómez
- M.A. García Esparza
- Carlos Barcia Mariño
- Manuel Monleón Pradas
- Jose Manuel García Verdugo
ISSN: 1888-6116
Año de publicación: 2009
Volumen: 20
Número: 2
Páginas: 69-74
Tipo: Artículo
Otras publicaciones en: Trauma
Resumen
Objective: To evaluate the performance of polymeric biomaterials based on hyaluronic acid and their usefulness in the central nervous system as support for cell differentiation and survival. Material and methods: With the purpose of assessing the viability of polymeric cannulated scaffolds, in vitro and in vivo experiments were made involving implantation in the Wistar rate brain cortex. Immunocytochemical and histological techniques were used to analyze scaffold viability. Results: Following culture, cell viability on the biomaterials was confirmed, together with the potential usefulness of the latter for the in vivo regeneration of vascular and neural structures. Conclusions: The possibility of regenerating vascular and neural structures through the implantation of biomaterials based on hyaluronic acid constitutes an advance in the use of biomaterials in the central nervous system