Estudio de los efectos de los inhibidores de mTOR en el trasplante renal

Laburpena

Long-term results of kidney transplantation are limited by the chronic graft failure and the death of the patient with a functioning kidney. Immunosuppressive drugs have an important role due to its effects on the graft (control of immune response and nephrotoxicity) and on vascular risk factors and the development of neoplasms. New immunosuppressive drugs, specially mTOR inhibitors have a better profile and are able to reduce both types of complications, increasing graft and patient survival. The present doctoral thesis analyzes the effects of this group of immunosuppressive drugs (Sirolimus and Everolimus) in renal transplant recipients. The effects of mTOR inhibitors over chronic graft damage in protocol kidney biopsies, on the appearance of proteinuria as a complication of its use in stable patients and on the formation of circulating regulatory T-cells in renal transplant patients are analyzed