Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development

  1. APELLANIZ UNZALU, BEATRIZ
Dirigida per:
  1. Jose Luis Nieva Escandón Director/a

Universitat de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 11 de de juny de 2012

Tribunal:
  1. Jesús Pérez Gil President
  2. Francesc Xabier Contreras Gómez Secretari/ària
  3. Enrique Pérez Payá Vocal
  4. Jamie K. Scott Vocal
  5. Gorka Basañez Asua Vocal

Tipus: Tesi

Teseo: 116155 DIALNET

Resum

1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.