Study of membrane proteome of DGKΖ-deficient cytotoxic T lymphocites

  1. Martínez Martínez, Gonzalo
Dirigida por:
  1. Isabel Mérida De San Román Director/a
  2. Severine Gharbi Codirector/a

Universidad de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 11 de octubre de 2019

Tribunal:
  1. Manuel Fresno Escudero Presidente/a
  2. Miguel Marcilla Goldaracena Secretario/a
  3. Concepcion Gil Garcia Vocal

Tipo: Tesis

Resumen

T cells are key cells in the coordination and implementation of the adaptive immune response. Specifically, cytotoxic T lymphocytes are responsible for eliminating cells presenting antigens on their surface either viral or tumor type. After antigen presentation, these cells must undergo a series of changes in the pattern of protein expression to reinforce the signaling capability and allow movement to the site of action. In case of membrane proteins, there are changes in expression of s...