Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgerya randomized and placebo-controlled clinical trial

  1. Luis Miguel Sáez Alcaide 1
  2. Pedro Molinero Mourelle 2
  3. José González Serrano 1
  4. Luis Jesús Rubio Alonso 1
  5. Michael M. Bornstein 3
  6. Juan López Quiles 1
  1. 1 Department of Dental Clinical Specialties. Faculty of Dentistry, Complutense University, Madrid, Spain
  2. 2 Department of Conservative Dentistry and Orofacial Prosthetics. Faculty of Dentistry, Complutense University, Madrid, Spain
  3. 3 Applied Oral Sciences and Community Dental Care. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China; Department of Oral Health & Medicine, University Center for Dental Medicine Basel UZB, University of Basel, Basel, Switzerland
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2020

Volumen: 25

Número: 5

Páginas: 10

Tipo: Artículo

DOI: 10.4317/MEDORAL.23661 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Objetivos de desarrollo sostenible

Resumen

The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery. A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). Swelling, trismus, postoperative pain, wound healing and complications were measured and recorded in order to evaluate differences between the placebo and experimental product. Five patients suffered from an alveolitis in the CG (13.9%), and none in the study group (0%), but no statistically significant difference was found (p=0.063). From day 0 to day 7, trismus and swelling were significantly less pronounced in the EG, and wound healing was considered ‘good’ in 22.2% for the CG and 97.2% for the EG (p<0.001). Mean VAS scores during the seven postoperative days were statistically lower in the study (2.56±1,19) compared to the placebo group (3.25±1.6) (p=0.002). The mean consumption of analgesic pills during the first 92 hours was also statistically lower in the EG (0.26±0.51) in comparison to the CG (0.56±0.67) (p=0.003). The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation. Future studies should further evaluate, if the gel is effective in dry socket preventing after third molar removal.

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Fuente de los datos: Dialnet