Risk factors related to oral candidiasis in patients with primary Sjögren’s syndrome

  1. Julia Serrano 1
  2. Rosa Mª López-Pintor Muñoz 2
  3. Lucía Ramírez Martínez Acitores 2
  4. Mónica Fernández Castro 3
  5. Mariano Sanz Alonso 2
  6. Sheila Melchor 4
  7. Diana Peiteado López 5
  8. Gonzalo Hernández Vallejo 2
  1. 1 Department of Dental Clinical Specialties, ORALMED research group, School of Dentistry, Complutense University, Madrid, Spain; PhD Student, Research training fellow, Complutense University, Madrid
  2. 2 Department of Dental Clinical Specialties, ORALMED research group, School of Dentistry, Complutense University, Madrid, Spain
  3. 3 Rheumatology Service, Hospital Puerta de Hierro, Madrid, Spain
  4. 4 Rheumatology Service, Hospital Doce de Octubre, Madrid, Spain
  5. 5 Rheumatology Service, Hospital La Paz, Madrid, Spain
Journal:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2020

Volume: 25

Issue: 5

Pages: 12

Type: Article

DOI: 10.4317/MEDORAL.23719 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Sustainable development goals

Abstract

Candidiasis is the most frequent mycotic infection of the oral cavity. The aim of this study was to investigate the presence of clinical oral candidiasis and Candida albicans yeast in a population diagnosed of primary Sjögren’s syndrome (pSS) and to study the possible factors associated with this infection. An observational cross-sectional study was conducted in 61 pSS patients (60 women, 1 man, mean age 57.64±13.52) where patient based information (demographic and medical, tobacco and alcohol consumption history), intraoral parameters (presence of dentures, clinical signs of candidiasis), salivary analytical information (number of Candida albicans as colony-forming units per millilitre (CFU/mL), salivary pH levels, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected. 13.1% of pSS patients presented oral signs of candidiasis. Denture stomatitis and angular cheilitis were the most common lesions. 87.5% of patients with clinical candidiasis presented reduced pH levels and salivary flow in both UWS and SWS. A significant statistical negative correlation was found between CFU/mL of Candida albicans and levels of UWS and SWS. A negative correlation was found between pH levels and CFU/mL, although not statistically significant. A reduced salivary flow may predispose pSS patients to Candida albicans overgrowth, which may show with clinical signs. Preventive measures are of great importance to avoid and to treat this condition promptly.

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