Utilidad del modelo murino para el estudio de la viruela de Actinobacilllus pleuropneumoniae

  1. Rodríguez Barbosa, José Ignacio
  2. Gutiérrez Martín, César B.
  3. Rodríguez Ferri, Elías Fernando
  4. Vázquez Boland, José Antonio
  5. Tascón Cabrero, R.I.
Anales de la Facultad de Veterinaria de León

ISSN: 0373-1170

Année de publication: 1992

Año: 38

Número: 38

Pages: 107-118

Type: Article

D'autres publications dans: Anales de la Facultad de Veterinaria de León


The usefulness of murine model for Actinobacillus pleuropneumoniae virulence studies was established by means of reference strains and field isolates LD5o determinations. One log differences allowed us to cluster strains in two groups. High virulence strains were those belonging to serotypes 1, 5, 9, 10, and 11, which produce ApxI hemolysin. The second group displayed a lower mortality and included strains of serotypes 2, 3, 4, 6, 7, and 8, which do not express ApxI. The major role of ApxI in A. pleuropneumoniae pathogenicity for mice was evidenced by these results. This animal model allowed us to establish differences between full-virulent strains and non-hemolytic mutants. Nevertheless, mice are unable to reproduce A. pleuropneumoniae natural infection and they seem to be only a good model for acute disease. Iron pool modification by iron dextran and Desferin° inoculation did not significantly improve the murine infection.