Not just the wallthe other ways to turn the yeast CWI pathway on

  1. Elena Jiménez 1
  2. Estíbaliz Alegría Carrasco 1
  3. Ángela Sellers Moya 1
  4. María Molina Martín 1
  5. Humberto Martín Brieva 1
  1. 1 Universidad Complutense de Madrid (IRICIS)
Journal:
International microbiology: official journal of the Spanish Society for Microbiology

ISSN: 1618-1905

Year of publication: 2020

Volume: 23

Issue: 1

Pages: 107-119

Type: Article

More publications in: International microbiology: official journal of the Spanish Society for Microbiology

Metrics

JCR (Journal Impact Factor)

  • Year 2020
  • Journal Impact Factor: 2.479
  • Journal Impact Factor without self cites: 2.425
  • Article influence score: 0.43
  • Best Quartile: Q3
  • Area: BIOTECHNOLOGY & APPLIED MICROBIOLOGY Quartile: Q3 Rank in area: 107/159 (Ranking edition: SCIE)
  • Area: MICROBIOLOGY Quartile: Q3 Rank in area: 101/136 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2020
  • SJR Journal Impact: 0.578
  • Best Quartile: Q3
  • Area: Microbiology Quartile: Q3 Rank in area: 105/169
  • Area: Microbiology (medical) Quartile: Q3 Rank in area: 68/131

Scopus CiteScore

  • Year 2020
  • CiteScore of the Journal : 2.8
  • Area: Microbiology (medical) Percentile: 45
  • Area: Microbiology Percentile: 29

Journal Citation Indicator (JCI)

  • Year 2020
  • Journal Citation Indicator (JCI): 0.41
  • Best Quartile: Q4
  • Area: MICROBIOLOGY Quartile: Q4 Rank in area: 124/151
  • Area: BIOTECHNOLOGY & APPLIED MICROBIOLOGY Quartile: Q4 Rank in area: 140/165

Abstract

The Saccharomyces cerevisiae cell wall integrity (CWI) pathway took this name when its role in the cell response to cell wall aggressions was clearly established. The receptors involved in sensing the damage, the relevant components operating in signaling to the MAPK Slt2, the transcription factors activated by this MAPK, as well as some key regulatory mechanisms have been identified and characterized along almost 30 years. However, other stimuli that do not alter specifically the yeast cell wall, including protein unfolding, low or high pH, or plasma membrane, oxidative and genotoxic stresses, have been also found to trigger the activation of this pathway. In this review, we compile almost forty non-cell wall-specific compounds or conditions, such as tunicamycin, hypo-osmotic shock, diamide, hydroxyurea, arsenate, and rapamycin, which induce these stresses. Relevant aspects of the CWI-mediated signaling in the response to these non-conventional pathway activators are discussed. The data presented here highlight the central and key position of the CWI pathway in the safeguard of yeast cells to a wide variety of external aggressions.