Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy
- Rouco Taboada, Helena
- Mariana Landín Pérez Doktorvater/Doktormutter
- Carmen Remuñán López Co-Doktorvater/Doktormutter
Universität der Verteidigung: Universidade de Santiago de Compostela
Fecha de defensa: 11 von März von 2021
- Ana Isabel Torres Suárez Präsidentin
- Carlos Alberto García González Sekretär/in
- Ana Margarida Moutinho Grenha Vocal
Art: Dissertation
Zusammenfassung
In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.