Cannabidiol for neuroprotection in newborn hypoxic-ischemic encephalopathy: pharmacological aspects and mechanisms of action

  1. Eldemerdash, Nagat Mohammed
Supervised by:
  1. José A. Martínez Orgado Director
  2. Ruth Pazos Rodríguez Director

Defence university: Universidad Autónoma de Madrid

Fecha de defensa: 09 July 2014

Committee:
  1. Jesús Argente Oliver Chair
  2. Julián Romero Paredes Secretary
  3. Ola Saugstad Committee member
  4. Javier Fernández Ruiz Committee member
  5. Eduardo Villamor Roldán Committee member

Type: Thesis

Teseo: 367124 DIALNET lock_openOpen access editor

Abstract

Hypoxia -ischemia in newborn is a world wide disease which haven't treatment yet. this disease is danger and affect between 2-9 for each 1000 newborn.newborn. Canabis recently enter to the field of brain damage. CBD is a new drug which has proved a very effective role to protect brain against brain damage. during the thesis , we have the hypothesis that CBD administration by a dose 1mg/kg could be anti-inflammatory anti Oxidation stress. in the thesis i had 2 modles of animals which have been also underwent the HI, then we administrate the CBD in one time point to test the nueroprotective affect also to study the mechanism of action , also we tested the temporary therapeutic window of CBD