Ácido úrico y síndrome metabólico en una población masculina de pilotos de líneas aéreas

  1. Juan Medina Font
  2. César Alonso Rodríguez
  3. Carlos Gutiérrez Ortega
  4. Pilar Montenegro Álvarez de Tejera
  5. Javier Gómez de los Terreros Sánchez
Journal:
Medicina y seguridad del trabajo

ISSN: 0465-546X,  1989-7790

Year of publication: 2012

Volume: 58

Issue: 226

Pages: 49-58

Type: Article

DOI: 10.4321/S0465-546X2012000100006 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina y seguridad del trabajo

Abstract

Fundamentals: Uric acid and metabolic syndrome are strongly related to cardiovascular disease. Objective: To assess the prevalence of metabolic syndrome as well as the levels of uric acid among aircrew members and to determine the relationship between the levels of uric acid and the prevalence of metabolic syndrome. Methods: We studied a population of 790 male airline pilots. We used the definition of metabolic syndrome of the National Cholesterol Education Program Adult Treatment Panel III, but modified by replacing waist circumference for the measurement of body mass index. Results: 25.4% of the pilots presented elevated level of uric acid. 19.9% of pilots presented metabolic syndrome. The risk to present metabolic syndrome in pilots with uric acid elevated in relation to those pilots with normal uric acid was 2.6 higher with a confidence interval of 95% between 2 and 3,4 with a significance of p<0.001. There is a positive linear association between the increased concentration of uric acid and the number of metabolic syndrome diagnostic criteria (p<0,001). Conclusions: Our results suggest that hyperuricemia can be a complication related to the metabolic syndrome. The abdominal obesity may condition an increased concentration of serum uric acid. It is necessary to increase the number of studies on aircrew members in relation to the above mentioned metabolic factors in order to increase the flight safety.

Bibliographic References

  • Frolich, ED. (1993). Eric acid: a risk for coronary Herat disease. JAMA. 270. 354-359
  • Niskanen, LK, Laaksonen, DE, Nyyssonen, K, Alfthan, G, Lakka, HM, Lakka, TA, Solonen, JT. (2004). Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men. Arch Int Med. 164. 1546-1551
  • Tykarski, A. (1991). Evaluation of renal handling of uric acid in essential hypertension: hyperuricemia related to decreased urate szecretion. Nephron. 59. 364-368
  • (2001). Expert Panel on the detection, Evaluation and Treatment of High blood cholesterol in Adults: Executive Summary of Third Report of the National cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 285. 2486-2497
  • Ford, ES, Mokdad, AH, Giles, WH. (2003). Trends in waist circumference among US adults. Obes Res. 11. 1223-1231
  • Assman, G, Jerzy-Roch, N, Schulte, H. (2004). Cardiovascular risk assessment in metabolic syndrome: View from PROCAM. Endocrinol Metab Clin N Am. 33. 377-392
  • Einhorn, D, Reaven, GM, Cobin, RH. (2003). American College of Endocrinology Position Statement on the Insulin Resistance Syndrome. Endocr Pract. 9. 237-252
  • Ferrannini, E, Natali, A, Bell, P, Cavallo-perin, P, Lalic, N, Mingrone, G. (1997). Insulin resistance and hypersecretion in obesity. J Clin Invest. 100. 1166-1173
  • (1996). The third national health and nutrition examination survey (NHANES III) reference manuals and reports. Centres for Disease Control and Prevention. Bethesda.
  • Yamasaki, T, Tomita, K. (2008). Relationship between hyperuricemia and metabolic syndrome. Nippon Rinsho. 66. 766-70
  • Onat, A, Uyarel, H, Hergenc, G, Karabulut, A, Albayrak, S, Sari, I, Yazici, M, Keles, I. (2006). Serum uric acid is a determinant of metabolic syndrome in a population-based estudy. Am J Hypertens. 19. 1055-62
  • López-Suárez, A, Elvira-González, J, Bascuñana-Quirell, A, Rosal-Obrador, J, Michán-Doña, A, Escribano-Serrano, J. (2006). FERUM urate levels and urinary acid excretion in subjects with metabolic síndrome. Med Clin (Barc). 126. 321-4
  • Sánchez-Chaparro,, MA, Calvo-Bonacho, E, González-Quintela, A, Fernández-Labandera, C, Cabrera, M, Sainz, JC. (2008). Occupation-related differences in the prevalence of metabolic síndrome. Diabetes Care. 31. 1884-1886
  • Hjortnaes, J, Algra, A, Olijhoek, J, Huisman, L, Jacobs, J, Van der Graaf, Y, Visseren, F. (2007). Serum uric acid levels and risk for vascular diseases in patients with metabolic síndrome. J Rheumatol.. 34. 1882-7
  • Chen, LK, Lin, MH, Lai, HY, Hwang, SJ, Chion, ST. (2008). Uric acid: a surrogate of insulin resistance in older woman. Maturitas. 59. 55-61
  • Gatti, A, Morini, E, Cosmo, SD, Maiani, F, Mandosi, E, Fallarino, M. (2008). Obesity. 16. 899-901
  • Alonso, C, Medina, J, Gutierrez, C. (2007). Prevalencia de síndrome metabólico en un colectivo de 762 pilotos de líneas aéreas españolas: Estudio 2003-2004. Med Aeroesp Ambient. 2. 64-71
  • Khazale, NS, Haddad, F. (2007). Prevalence and characteristics of metabolic syndrome in 111 Royal Jordinian Air Force pilots. Aviat Space Environ Med. 78. 968-72
  • Alonso, C, Medina, J, Gutiérrez, C. (2008). Prevalencia de síndrome metabólico en pilotos de líneas aéreas españolas de diferentes grupos de edad: Estudio 2007. Av Diabetol.. 24. 231-236
Data source: Dialnet