Descompensación corneal en pacientes con compromiso endotelial tratados con dorzolamida tópica

  1. Domingo Gordo B 1
  2. Urcelay Segura JL 1
  3. Conejero Arroyo J 1
  4. Balado Vázquez P 1
  5. Rodríguez Ausín P 1
  1. 1 Hospital General Universitario Gregorio Marañón
    info

    Hospital General Universitario Gregorio Marañón

    Madrid, España

    ROR https://ror.org/0111es613

Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2002

Volume: 77

Issue: 3

Pages: 139-144

Type: Article

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More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Purpose To investigate the posibility of corneal alterations in patients with long-term endothelial compromise with topical dorzolamide. Material and methods Retrospective descriptive study of 17 patients with penetrating keratoplasty and glaucoma associated with topical carbonic anhydrase inhibitor therapy, looking for coincidence with corneal alteration. Results Classified by ethiology, type of glaucoma and control, recording previous ophthalmological surgeries, evolution time, complications and rejection episodes. Seven patients suffered a corneal decompensation, in three of them there were signs of true reject but only four cases had edema at the beginning of dorzolamide treatment, one of them recovering after stopping dorzolamide. Risk factors were previous cataract surgery, mainly aphakia, filtering surgery and previous vitrectomy. Conclusions Dorzolamide could have a potential negative effect on patients with endothelial compromise.

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