Papel de MINDIN en la progresión tumoral y formación del nicho pre-metastásico óseo en el cáncer de próstata

Abstract

Prostate cancer is one of the main pathologies that affect the male population. However, the determining factors in its development are unknown. Currently, the challenge in prostate cancer is the identification of specific tumor markers, essential to predict and monitor prostate tumors with the aim of reducing mortality and maintaining an acceptable quality of life.Bone is a dynamic tissue that continually remodels in response of a wide variety of stimuli. In addition, it is an organ frequently infiltrated by the metastatic spread of solid tumors, such as prostate cancer. This preference, called organotropism, may be due to the acquisition of osteomimetic characteristics by tumor cells. Osteomimicry implies that tumor cells ectopically express genes restricted to bone tissue and predispose them to colonize it...