Caracterización molecular de cáncer colorrectal metacrónico

Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors, being the second cancer with the highest mortality worldwide. CRC is a heterogeneous disease that develops through different carcinogenic pathways, where both genetic and epigenetic changes are involved.Patients diagnosed with CRC have an increased risk of developing other lesions along the colon after surgery, detected during follow-up - metachronous CRC (MCRC) -. Although genomic studies carried out have improved our ability to identify the molecular changes associated with CRC, molecular basis and risk factors associated with MCRC remain poorly understood. Evidence suggests that hereditary CRC syndromes are one of the risk factors for developing MCRC, however it is still unknown which patients are prone to this condition...