Supervivientes oligometastásicosdependencia sociosanitaria post-radioterapia craneal intensiva

  1. Sallabanda Hajro, Morena
Supervised by:
  1. María Isabel García Berrocal Director
  2. Felipe A. Calvo Manuel Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 28 January 2021

Committee:
  1. José Luis Carreras Delgado Chair
  2. Paloma Ortega Molina Secretary
  3. Jesus Romero Fernandez Committee member
  4. José Javier Aristu Mendioroz Committee member
  5. Rebeca Pérez Alfayate Committee member

Type: Thesis

Teseo: 155167 DIALNET lock_openDocta Complutense editor

Abstract

Brain metastases (BM) are the most common brain tumors in adults. The primary endpoint of this study is to assess treatment outcome and prognostic factors associated with prolonged survival in patients with BM treated with stereotacticradio surgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). As secondary endpoints, the relationship of dose in the hippocampal area with the neurocognitive state and quality of life of long survivors is evaluated. Patients and methods:This study retrospectively reviewed 200 oligometastatic patients with 324 BM treated with one fraction (15–21 Gy) or 5–10 fractions (25–40 Gy) between January 2010 and August 2016. 26.5% of patients received whole brain radiotherapy (WBRT) and 25% initial surgery. Demographics, prognostic scales, systemic and local control, patterns of relapse and rescue, toxicity and cause ofdeath were analyzed. A stratified analysis by primary tumor was done. Moreover, 11 long survivors were evaluated with quality of life and neurocognitive tests...