Consecuencias de obesidad y síndrome metabólico en diálisis

Resumo

Obesity is defined by the World Health Organization (WHO) as an excessive accumulation of body fat that can be hazardous to human health.Body Mass Index is the most widely used diagnostic criteria for obesity. It is defined as Weight/Height2. It is easy to calculate, and it has been related with hypertension, diabetes and total and cardiovascular mortality. However, big epidemiological studies in dialysis patients have evidence that BMI can be related with better survival. This finding is called “The obesity paradox” and there are lots of papers trying to explain why obesity can increase survival in these patients. Adipose tissue secretes some cytokines involved in metabolic pathways and inflammation, also in dialysis patients. Chronic kidney disease is related with a chronic inflammatory status and a high risk of weight loss and malnutrition. This protein energy wasting is one of the most important mortality risk factors in dialysis patients...