Efecto del cannabidiol sobre la hemorragia de la matriz germinal producida en neonatos prematuros

  1. Pozo Sanz, Aaron del
Supervised by:
  1. Ana Gutiérrez Rodríguez Director
  2. José A. Martínez Orgado Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 11 June 2021

Committee:
  1. Javier Fernández Ruiz Chair
  2. Luis Arruza Gómez Secretary
  3. Carmen Guaza Rodriguez Committee member
  4. Alejandro Higuera Matas Committee member
  5. Julián Romero Paredes Committee member
Department:
  1. Salud Pública y Materno-Infantil

Type: Thesis

Teseo: 155456 DIALNET lock_openDocta Complutense editor

Abstract

Cerebral palsy (CP) is the most severe and frequent disabling disease in childhood, including motor, cognitive and sensorial sequelae. Studies on CP causes are difficult because of its multifactorial etiology. Anyway, low gestational age and/or birth weight are major determinants pf CP . Extreme preterm (EP) and extreme low birth weight (ELBW) newborns are those under 25 weeks of gestational age and 1000 g of birth weight, respectively. Due to the immaturity of central nervous system (CNS) in those babies, both EP and ELBW have been considered of highest risk to develop CP. An important factor explaining such a high risk is the high incidence of intraventricular hemorrhage (IVH) in those patients. IVH is the most common type of cerebral hemorrhage in newborns and a major cause of white matter injury (WMI) and then of CP development...