Control de la leishmaniosis caninaevaluación de nuevas alternativas profilácticas y terapéuticas

Abstract

Canine visceral leishmaniosis is an important zoonotic parasitic disease, with dogs infected with Leishmania infantum the main urban reservoirs of this pathology and they play an important role in the transmission of disease to humans. In recent years, numerous advances have been made in the knowledge of biology, epidemiology, pathology, diagnosis, treatment, prevention and control of this disease; however, to date, no cure and prophylaxis has been achieved in one hundred percent of cases in the urban host of visceral leishmaniosis that is the dog. Given the interest of canine leishmaniosis in clinical veterinarians, owners and breeders of dogs, together with the added health importance due to its zoonotic character in endemic areas, we have felt it appropriate to conduct this study in order to evaluate new approaches in the field of canine leishmaniosis control by studying and monitoring the infectious, immunogenic and protective capacity of experimental infection of Beagle dogs, with non-virulent strains of Leishmania infantum isolated from patients co-infected with HIV and evaluating the safety, pharmacokinetic behavior and therapeutic efficacy of a new inosomated formulation associating sodium stibogluconate and paromomycin in the treatment of symptomatic dogs experimentally infected with L. infantum, through three clinical trials...