Papel de C3G en la diseminación, tumorigénesis y señalización celular del glioblastoma

  1. Manzano Figueroa, Sara
Supervised by:
  1. Álvaro Gutiérrez Uzquiza Director
  2. Almudena Porras Gallo Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 22 March 2021

Committee:
  1. Guillermo Velasco Díez Chair
  2. Mª Dolores Martín de Saavedra Álvarez Uribarri Secretary
  3. Flavio Maina Committee member
  4. Eugenio Miguel Ángel Santos de Dios Committee member
  5. Catalina Ribas Núñez Committee member
Department:
  1. Bioquímica y Biología Molecular

Type: Thesis

Teseo: 155614 DIALNET lock_openDocta Complutense editor

Abstract

GBMs (glioblastomas), or grade IV astrocytomas/gliomas, are the most frequent and aggressive brain tumours, whose diagnosis and treatment is still inefficient. RTKs (receptor tyrosine-kinases), mainly EGFR, and their downstream pathways are altered in almost 90% GBMs. RTKs, are relevant for the regulation of GBM tumourigenesis and dissemination and for GSCs (GBM stem cells), a GBM subpopulation that display stem-like and GBM-initiating properties. Dissemination is also linked to GBM aggressiveness. EMT (epithelial-mesenchymal transition)-like processes would facilitate the acquisition of a more mesenchymal and invasive phenotype. Both, stemness and disseminative capacity have been associated to GBM recurrence and therapy resistance...