Novel ligand-based 19f-nmr and computational approaches for studying sugar-lectin molecular recognition events
- Martínez Ordóñez, José Daniel
- Jesús Jiménez Barbero Director
- Francisco Javier Cañada Vicinay Director
Universidade de defensa: Universidad Complutense de Madrid
Fecha de defensa: 08 de xuño de 2021
- María Angeles Canales Mayordomo Presidenta
- Maria del Henar Vazquez Villa Secretaria
- Gonzalo Jiménez Oses Vogal
- Filipa Margarida Barradas de Morais Marcelo Vogal
- Francisco Corzana López Vogal
Tipo: Tese
Resumo
Carbohydrates play a central role in a large myriad of biological processes. They are found in all living organisms in nature, participating in different functions ranging from their use as energy source or as structural fragments, to infection-related processes in complex organisms. In vertebrates, they are located both in the cell surface and in the extracellular space, forming very diverse and intricate structures, but they are also present in the nucleus and cytoplasm of eukaryotic cells bound to proteins (glycoproteins). Their location almost ubiquitous in the organism confers them the capacity of mediate in a large number of ‘communication’ processes with other entities, for instance, in cell-cell, cell-molecule and cell-matrix interactions. In addition, carbohydrates intervene in molecular recognition processes between different organisms, such as the pathogen and parasite recognition by host cells...