Efecto del compuesto correlacionado de hexosa activo (AHCC) en patologías inflamatorias intestinalestriquinosis y enfermedad inflamatoria intestinal (EII)

  1. López Cauce, Beatriz
Dirigée par:
  1. Juan José García Rodríguez Directeur
  2. Marta Puerto Cantero Directeur/trice
  3. Luis Alberto Menchén Viso Directeur

Université de défendre: Universidad Complutense de Madrid

Fecha de defensa: 04 juin 2021

Jury:
  1. Eduardo Martínez Naves President
  2. Alicia Gómez Barrio Secrétaire
  3. José Antonio Pajares Díaz Rapporteur
  4. Rosa del Campo Moreno Rapporteur
  5. Manuel Barreiro de Acosta Rapporteur
Département:
  1. Medicina

Type: Thèses

Teseo: 155649 DIALNET lock_openDocta Complutense editor

Résumé

AHCC is a natural product discovered in 1986 and patented by the Japanese company Amino up, which is obtained from the fermentation of the mycelium of the L. edodes fungus. It is described as a nutraceutical or an immunomodulator due to its ability to modulate the immune response to challenges of different etiology (1). Currently, it is used as concomitant treatment in cancer patients, since it reduces the generalized effects of chemotherapy (2-5).In the present work, we wanted to test the effects of AHCC in an organ where the regulation of the immune system is fundamental: the intestine. To do this, several models were used: the murine model of trichinosis and models of inflammatory bowel disease (IBD), both acute and chronic (6, 7)...