Identificación de aislamientos clínicos y ambientales de Nocardia spp. mediante técnicas genómicas y proteómicas

Abstract

The genus Nocardia is located within the order Corynebacteriales, together with Conynebacterium and Mycobacterium, and they are Gram-positive branched bacilli with a high content of G+C. It comprises about 200 species of wide environmental distribution that grow slowly under aerobic conditions as separate colonies with different morphologies, producing primary mycelia that can be fragmented into hyphae with a coccoid shape. They are responsible for opportunistic infections in humans, mainly in immunosuppressed patients, with diabetes or neoplasms, immunosenescent, solid organ transplants, or in treatment with immunosuppressive drugs or corticosteroids. It mainly affects the lungs and cutaneous and subcutaneous tissues, but can spread to the Central Nervous System, the eyes, and other regions. This ability to spread, the presence of abscesses and granulomas, relapses, becoming chronic infection can make treatment challenging. In addition, like other Actinobacteria, it has a high biosynthetic capacity, which has aroused the interest of the pharmaceutical industry...