Opciones terapéuticas en el tratamiento de la enfermedad de Alzheimer

1. M. Alonso ¹
2. M.C. Villa-Hermosilla ¹
3. A.I. Fraguas-Sánchez ¹
4. A. Fernández-Carballido ¹
5. E. Barcia ¹

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Abstract

Alzheimer’s disease is the leading cause of dementia in the world today. The very first causes of this pathology are not clear, however, the mechanisms that induces neuronal death are known. These mechanisms are the accumulation of peptide Aβ, the precipitation of hyperphosphorylated Tau protein and the damage caused by reactive oxygen species. As this disease has a multifactorial development, there is no effective treatment. Current treatments are only capable of slowing the progress of the disease. The most widely used treatments in this pathology are acetylcholinesterase inhibitors and memantine, non-steroidal anti-inflammatory drugs, neuroprotectors and monoclonal antibodies are also studied for their use in.

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