¿Afecta el plomo la fagocitosis de macrófagos peritoneales?

1. Villanueva, R.
2. Albaladejo, R.
3. Ortega, P.
4. Astasio, P.
5. Calle, M.E.
6. Gil, A.
7. Dominguez-Rojas, V.

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More publications in: Revista de toxicología

Abstract

Subclinical exposure to Pb doses produces immune alterations both in humans and animals. We propose to look at the effects of 13, 130 and 1300 ppm of lead on phagocytosis, candidicide activity of mouse resident peritoneal macrophages and adherence of C. albicans to said phagocytes. Phagocytosis, candidicide activity and adherence of C. albicans are assessed using modifications of Zeligs technique. Phagocytosis assessed using average number of C. albicans per macrophage dropped in proportion to their exposure to lead (variance analysis p = 0.018) with no variation in the other parameters measured. Lead may reduce phagocytosis speed by lesions in the membrane and myosin ATPases or by inhibiting the assemblage of the microtubules, which would lead to a deficient ingestion of the fungus.

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