Proteínas de adhesiónLaminina y fibronectina en el periodonto
- J. Turnay
- N. Olmo
- Mª.T. López-Conejo
- J.Mª. Navarro
- Mª.A. Lizarbe
ISSN: 1699-6585
Year of publication: 1995
Volume: 7
Issue: 3
Pages: 129-138
Type: Article
More publications in: Avances en periodoncia e implantología oral
Abstract
One of the factors that influences the development of periodontal desease is the detachment of the gingiva from the tooth surface and the apical proliferation of the junctional epithelium. Modification in cell adhesion parallel to alterations in the extracellular matrix component are observed in this process. The tissue breakdown is partly mediated by enzimes derived from bacteria and tissue. Collagen, fibronectic and laminin are substractes available for enzyme activity. In fact, the bacterial colonization of the dental surface is one of the mechanisms that triggers periodontal disease, inducing the destruction of the gingival-periodontal supporting tissues. In this report we review some of the extracellular matrix components in order to analyze some aspects of periodontal disease in which adhesion proteins may play a role. Among them, we report mainly on two multifunctional glycoproteins, laminin and fibronectin which have been show to stimulate a variety of biological processes. The effect of some components of the bacterial plaque on the binding to and degradation of these molecules in the development of periodontitis is analyzed.