Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration

  1. Contreras, Inés 12
  2. Hurtado-Ceña, Francisco Javier 1
  3. Pérez-Carrasco, María Jesús 3
  4. Puell, María Cinta 3
  1. 1 Clínica Rementería, Madrid, Spain
  2. 2 Hospital Ramón y Cajal, Opthalmology, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain
  3. 3 Applied Vision Research Group, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain
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Revista:
European Journal of Ophthalmology

ISSN: 1120-6721,  1724-6016

Año de publicación: 2020

Páginas: 112067212096874

Tipo: Artículo

DOI: 10.1177/1120672120968740 PMID: 33153337 GOOGLE SCHOLAR

Otras publicaciones en: European Journal of Ophthalmology

Resumen

Purpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA ( p  = 0.001). CRT emerged as the only independent predictor of LLD ( p  = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.

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