Papel de la IL-6 y TNF-α en la enfermedad periodontal
- Carrillo de Albornoz Sainz, Ana
- García Kass, Ana Isabel
- Bascones Martínez, Antonio
ISSN: 1699-6585
Year of publication: 2006
Volume: 18
Issue: 2
Pages: 83-89
Type: Article
More publications in: Avances en periodoncia e implantología oral
Sustainable development goals
Abstract
Periodontal disease is iniciated by several pathogens which induce an inflammatory cascade which stimulates the tisular destruction mediated by the host. Many inflammatory mediators are involved in this process. Amongst them we can remark IL-6 and TNF-α. IL-6 is a pleiotropic citokine of complex biological activity, which principal function linked to periodontitis is the induction of osseous resorption. TNF-α is a proinflammatory citokine which main function is the recruitment and stimulation of neutrophils and monocytes. Its role upon periodontitis is diverse. It gives rise to inflammation, as well as osseous resorption and connective tissue destruction, and limitates the reparative potential of periodontium.