AINEs como tratamiento coadyuvante de la enfermedad periodontal

Resum

A review about the application of antiinflammatories as an aid for the periodontal treatment is presented. After a brief introduction, we explain the immunological bases of periodontal inflamation and tissue destruction, focusing on arachidonic acid metabolism and the four most important inflammatory mediators now in periodontal tissue resorption: prostaglandin E₂ (PGE₂), prostaglandin F₂α (PGF₂α), leucotriene B₄ (LTB₄) and platelet activation factor (PAF), and explaining their actions and role in inflammation through matrix metalloproteinase (MMPs) and their relation with some other mediators in the inflammatory chain also related with tissue resorption. After, we expound some of the most used drugs for the inhibition of all of these mediators (non-steroid antiinflammatory drugs or NSAIDs, omega3 fatty acids, tetracyclines and bisfosfonates), explaining their action and the papers wich investigated them and later we have made a compilation of the few studies making clinical measurements to finish establishing some conclusions.