1. Envejecimiento neuronal entérico. 2. Efecto del D9-THC y el WIN 55.212-2 sobre la unión neuromuscular del diafragma de rata

Resum

The study of pain treatment in aged people has been of increasing interest in the last few years, due to the progressive aging of the population and due to the fact that control of pain is essential to keep quality of life and daily activity of these people. But the pharmacological treatment of pain in aged people is complicated, because in these population altered responses and adverse reactions to drugs, plus drugs interaction, are much more frequent. Drugs indice alteration in the gastrointestinal motility. In this regard, it would be very interesting to know how the structure and function of the gastrointestinal tract change with age. This knowledge would help to reduce the pharmacological complications in the elderly, allowing the improvement of pain treatment. On the other hand, the study of pharmacological targets of the new therapeutic agents is important. Nowadays, cannabinoids are being very studied due to their potential therapeutic effect in many diseases. In this sense, cannabinoids could be useful in the treatment of some symptoms of multiple-sclerosis, Parkonson, spinal cord injury..., like spasticity or muscular pain. It would be necessary to know the effect of cannabinoids on the different types of skeletal muscle. Furthermore, a peropheral target for cannabinoids could avoid the central adverse effect, improving the therapeutic response. Therefore, this doctoral thesis will consist of two parts: Entering neuronal aging (carried out at the Área de Farmacología, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid). Evaluation of the cannabinoid effect on the rat neuromuscular junction (carried out at the Institute of Biomedical Science, University of Aberdeen, Aberdeen, Scothland.