Esporos bacterianos para el tratamiento del cáncer.

Abstract

Currently, cancer treatment methods used are still very harmful for the body and often ineffective. The resolution of solids tumors with hypoxia zones has major disadvantages. There are many scientists who opt for the use of bacteria and their forms of resistance, the spores, as treatment alternatives. Different studies have confirmed the advantages of the use of bacterial spores (Clostridium novyi-NT, Clostridium sporogenes ATCC13732, and Clostridium beijerinckii NCIMB 8052). These are stable till they reach areas with the permissive concrete conditions for germination (hypoxia), and can be administered by systemic route. The antitumor effect is based on the hydrolytic enzymes production (proteases, nucleases and lipases) and a nutritional competition between bacterium and neoplastic cells. Using genome modification techniques deleterious genes have been removed and others to improve their effectiveness have been inserted. And finally, they can be combined with other treatments (COBALT combination bacteriolytic therapy). The use of genetic modified spores represents a new horizon in cancer treatment, especially in inaccessible regions of the tumor.