Efecto del piretroide deltametrina sobre los niveles de monoaminas en diferentes regiones cerebrales de rata
- Fernandez, M.C.
- Martinez-Larranaga, M.R.
- Diaz, M.J.
- Fernandez-Cruz, M.L.
- Bringas, P.
- Martinez, M.A.
- Anadon, A.
ISSN: 0212-7113
Any de publicació: 1995
Volum: 12
Número: 1
Pàgines: 20-23
Tipus: Article
Altres publicacions en: Revista de toxicología
Resum
Both types of pyrethroid insecticides (Type I and Type II) are recognized as agents acting specifically on the nervous system. The present experiment was designed to study the effects of deltamethrin (Type II pyrethroid) on the levels of 5-hydroxytryptamine (5-HT), 5-hydroxy-3-indole acetic acid (5-HIAA), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and noradrenaline (NA) in various brain regions of the rat. Deltamethrin (40 mg/kg, i.p., once a day for 8 consecutive days) produced an increase in the levels of 5-HIAA in hypothalamus, caudate putamen and medula oblongata, and only altered significantly the levels of 5-HT in hypothalamus. Deltamethrin increased 5-HT turnover in all the areas studied. Moreover, deltamethrin produced an increase in the levels of DA, DOPAC and HVA in hypothalamus and caudate putamen without affecting the turnover of DA in these CNS areas. These results indicate that deltamethrin is able to affect both 5-HT-ergic and dopaminergic neurotransmission. It seems likely that such effects could be due to interaction with GABAergic system.