Stereoselective organic synthesis in water: Organocatalysis by proline and its derivatives

  1. Vinoth, Perumal
  2. Karuppasamy, Muthu
  3. Menéndez, J. Carlos
  4. Vachan, B.S.
  5. Sridharan, Vellaisamy
Liburua:
Green Sustainable Process for Chemical and Environmental Engineering and Science

Argitaletxea: Elsevier

ISBN: 978-0-12-819542-0

Argitalpen urtea: 2020

Orrialdeak: 191-229

Mota: Liburuko kapitulua

DOI: 10.1016/B978-0-12-819542-0.00006-3 GOOGLE SCHOLAR lock_openSarbide irekia editor

Laburpena

Water is not flammable, has no smell, is nontoxic and is easily separated from the products of organic reactions. Furthermore, when used as a reaction medium it often enhances the rate and selectivities of many organic reactions or leads to alternative reaction modes. Due to these features, stereoselective organocatalysis in water has attracted much interest from synthetic chemists. We summarize in this chapter the main developments on stereoselective reactions performed in water and using proline or proline derivatives as catalysts. Reactions catalyzed by solid-supported proline derivatives are also discussed in detail.