Teixobactina, un nuevo antibiótico que difícilmente podría originar resistencias
ISSN: 1697-4298, 0034-0618
Año de publicación: 2015
Volumen: 81
Número: 1
Páginas: 4-10
Tipo: Artículo
Otras publicaciones en: Anales de la Real Academia Nacional de Farmacia
Resumen
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. In a recent publication has been described a new antibiotic of depsipeptide nature named teixobactin that was discovered in a screen of uncultured soil bacteria (1). This compound inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). The method developed in its discovery and the apparent ability of teixobactin to avoid resistances, may open a path towards the development of other clinicaly useful antibiotics.