Inhibidores BET. El singular compuesto (+)-JQ1
ISSN: 1697-4298, 0034-0618
Año de publicación: 2015
Volumen: 81
Número: 3
Páginas: 214-220
Tipo: Artículo
Otras publicaciones en: Anales de la Real Academia Nacional de Farmacia
Resumen
The serendipitous discovery of (bromodomain extra-terminal) (BET) inhibitors, especially of the BRD4 bromodomain inhibitors, has allowed modulation of gene transcription with epigenetic drugs. This is the case of protooncogen c- MY C and other genes involved in carcinogenesis and different disfunctions. These drugs, that include the compound (+)-JQ1, have shown their potencial as anticancer agents, immunomodulators, male contraceptives, antiviral, or heart failure chemopreventive agents, among others. In this review we analyze their discovery, structure, mechanism of action and future perspectives.