Pathogenesis of oral cancer caused by human papilloma virus
- Peña Cardelles, Juan Francisco
- Cano Durán, Jorge Antonio
- Ortega Concepción, Daniel
- Mansilla Romani, Mario Santos
- Rivera Gómez, Begoña 1
- Hernández Vallejo, Gonzalo 1
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1
Universidad Complutense de Madrid
info
ISSN: 1697-6398, 1697-641X
Año de publicación: 2017
Volumen: 14
Número: 4
Páginas: 18-26
Tipo: Artículo
Otras publicaciones en: Científica dental: Revista científica de formación continuada
Resumen
Introduction: Oral cancer represents 1-2% of all cancers in the body, 90% of which is correspond to oral squamous cell carcinoma (OSCC). Risk factors traditionally involved in the development of oral cancer are advanced age, male sex, and prolonged expo-sure to habits such as alcohol, tobacco, and betel nut. In recent years, the increasing incidence of OSCC in young patients without exposure to classical risk factorssuggests the presence of other possible pathogenic agents, especially the Human Papilloma Virus (HPV). Objectives: To reveal on the molecular development of OSCC by HPV as an oncovirus and its characteristics. Results: The studies show the high oncogenic risk presented by HPV subtypes 16 and 18 acting via their E6 and E7 proteins, directly affecting p53, on retinoblastoma (pRb) and other enzymesinvolved in regulation of the cell cycle like PI3K, thereby altering processes of cellular apoptosis, proliferation and differentiation. Conclusions: HPV plays an important role as a carcinogen in the onset of OSCC associating a more favorable prognosis compared to other etiologic factors. The process of oncogenesis in the development of OSCC caused by HPV is linked to the high-risk subtypes, as well asthe expression of viral proteins E6 and E7, which are responsible for inhibiting the activity of cell cycle tumorsuppressor genes.