Physiology and modulation factors of ovulation in rabbit reproduction management

  1. Mattioli, Simona 1
  2. Maranesi, Margherita 1
  3. Castellini, Cesare 1
  4. Dal Bosco, Alessandro 1
  5. Arias-Álvarez, Maria 2
  6. Lorenzo, Pedro Luis 2
  7. García Rebollar, Pilar 3
  8. García-García, Rosa María 2
  1. 1 Università di Perugia
    info

    Università di Perugia

    Perugia, Italia

    ROR https://ror.org/00x27da85

  2. 2 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

  3. 3 Polytechnic University of Madrid
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Revista:
World Rabbit Science

ISSN: 1989-8886,  1257-5011

Año de publicación: 2021

Volumen: 29

Número: 4

Páginas: 221-229

Tipo: Artículo

DOI: 10.4995/WRS.2021.13184 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: World Rabbit Science

Resumen

Rabbit is an induced ovulatory species, so ovulation takes place after mating. Traditionally, exogenous and synthetic hormonal factors (administered by intramuscular and intravaginal route) such as GnRH and analogues, or different physical procedures (i.e. stimulation by intravaginal cannula) have been used to induce ovulation in females when artificial insemination is applied in rabbit farms. Restriction and public rejection of the use of hormones is leading to the study of the seminal plasma components with potential action on ovulation induction. The aim of the present review is to collect and summarise the strategies used in recent years to trigger ovulation and improve rabbit fertility management with respect to more animal-friendly manipulation methods. Furthermore, special attention has been paid to the use of a semen component (as endogen molecule) such as beta nerve growth factor (β-NGF) in male and female rabbit reproductive physiology. This neurotrophin and its receptors (TrKA and p75NTR) are abundantly distributed in both male and female rabbit reproductive tracts, and it seems to have an important physiological role in sperm maturation and behaviour (velocity, apoptosis and capacitation), as well as a modulatory factor of ovulation. Endogen β-NGF is diluted in the seminal doses with the extenders; hence it could be considered an innovative and alternative strategy to avoid the current exogenous (by intramuscular route) and stressful hormonal treatments used in ovulation induction. Their addition in seminal dose could be more physiological and improve animal welfare in rabbit farms.

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