Prolongación en el tiempo del efecto del esmolol sobre la regresión del remodelado coronario en ratas espontáneamente hipertensas

Abstract

Hypertension is responsible for both cardiac and vascular remodeling, leading to adverse cardiac events, such as arrhythmias, heart failure or acute myocardial infarction, increasing morbidity and mortality. There are several antihypertensive drugs that have been shown their ability to reverse this remodeling, thus improving the prognosis of patients, but their beneficial effect appears after months or even years of continuous treatment. Esmolol is a drug that belongs to the group of cardioselective beta-blockers with certain pharmacokinetic peculiarities, with a negative chronotropic effect and an important ultra-rapid and powerful hypotensive effect, widely used in routine clinical practice...