N-acilhomoserina lactona acilasa de Actinoplanes utahensiscaracterización e interés biotecnológico

Abstract

N-acyl-L-homoserine lactones (AHLs) are small signal molecules involved in intercellular communication processes, known as quorum sensing (QS), in Gram-negative bacteria. QS allows a bacterial community to synchronize the expression of a set of target genes in order to respond to environmental changes in a density-dependent manner. Several biological functions such as antibiotic production, secretion of virulence factors, biofilm formation, bioluminescence or conjugation are regulated by this mechanism. QS interference processes, known as Quorum Quenching (QQ), are an alternative antimicrobial therapy for inhibiting virulence mechanisms of pathogenic bacteria without affecting cell growth. One of the QQ strategies consists in the enzymatic degradation or modification of the autoinducers, being acylases one of the main groups of AHL degrading enzymes...