Nuevas estrategias sintéticas estereocontroladas basadas en lactamas y alenosaplicación a la preparación de heterociclos potencialmente bioactivos

Resumo

Since their discovery, allenes have been identified as an unusual structure in Organic Chemistry. Allenes are capable of showing reactivity to various substrates but these types of compounds have attracted less attention from research groups incomparison with the chemistry of analogous functional groups such as alkenes oralkynes. Carbocyclization and heterocyclization reactions catalyzed by transition metals are the most common rearrangement. In this manner, compounds with chemical and biological interest have been achieved. On the other hand, alkynes are one of the most versatile functional groups in Organic Chemistry. Since 2014, photoredox catalysis between alkynes and diazonium salts has received significant attention. The use of organic promoters such as gallic acid, L-ascorbic acid or 1,2,3-triolbenzene, is continuously growing in order to avoid the toxicity of transition metals...