Papel del glicocálix como marcador de la disfunción endotelial secundaria al daño por isquemia reperfusión

Abstract

Ischaemia-reperfusion (I/R) injury is a main cause of morbidity after intestinal resection surgeries. The I/R syndrome is very frequent and takes part in many processes like equine colic, one of the most common emergency inhorses, which present a high mortality and morbidity rates. It includes a deficient blood supply to tissues that causes the alteration of the cellular metabolism followed by the reperfusión of the ischemic cells, which increased the metabolic alteration and it is worsen by the presence of reactive oxygen species (ROS). Although the severity of the damage resulting from I/R varies between tissues, a common component of this pathologic process for all organs is the microvascular dysfunction. In fact, after I/R, endothelial cells suffer from increased oxidative stress and they exhibit swelling and detachment from the basement membrane. Consequently, leukocytes adhere and transmigrate and vascular permeability increases. In equine colics, the consequences caused by this phenomenon range from severe mucosal damage or barrier dysfunction, to endotoxic shock and death...