Nanopartículas de Morin funcionalizadas con fenilalanina para el tratamiento de la enfermedad de Alzheimer

  1. Alonso Gonzalez, Mario
Supervised by:
  1. Emilia María Barcia Hernández Director
  2. Ana Fernández Carballido Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 27 September 2021

Committee:
  1. Santiago Torrado Durán Chair
  2. Ana Isabel Fraguas Sánchez Secretary
  3. María Consuelo Montejo Rubio Committee member
  4. Jesús Molpeceres García del Pozo Committee member
  5. María Luisa González Rodríguez Committee member
Department:
  1. Farmacia Galénica y Tecnología Alimentaria

Type: Thesis

Teseo: 156517 DIALNET lock_openDocta Complutense editor

Abstract

Morin hydrate (MH) is a flavonoid of plant origin, which has been shown in vitro to have activity against neurodegeneration mechanisms associated with Alzheimer's disease (AD), avoiding hyperphosphorylation of the Tau protein, dissolving β-amyloid peptide aggregates that form senile plaques and reducing oxidative stress produced by reactive oxygen species. Its potential clinical use is very limited due to its low bioavailability, rapid liver metabolism, and poor ability to cross the blood-brain barrier (BBB)...