North African genetic variation of cytochrome and sulfotransferase genes

  1. Gaibar, María 1
  2. Arqués, Meritxell 2
  3. Fernández-Santander, Ana 1
  4. Novillo, Apolonia 1
  5. Romero-Lorca, Alicia 1
  6. Wei Li, Qi 1
  7. Esteban, M. Esther 2
  1. 1 Universidad Europea de Madrid
    info

    Universidad Europea de Madrid

    Madrid, España

    ROR https://ror.org/04dp46240

  2. 2 Universitat de Barcelona
    info

    Universitat de Barcelona

    Barcelona, España

    ROR https://ror.org/021018s57

Revista:
International Journal of Modern Anthropology

ISSN: 1737-8176,  1737-7374

Año de publicación: 2015

Volumen: 1

Número: 8

Páginas: 13

Tipo: Artículo

DOI: 10.4314/IJMA.V1I8.1 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: International Journal of Modern Anthropology

Resumen

This review is focused on the genetic variation of sulfotransferases (SULTs) andcytochromes (CYPs) genes among different ethnic groups, mainly focusing in variation inNorth African populations. Polymorphisms of SULTs and CYPs proteins are associated withaltered enzymatic activity and physical characteristics. Single nucleotide polymorphisms (SNP)in these genes have shown relevant ethnic differences among Sub-Saharan African andEuropean groups that might contribute to understand the variability in drug metabolism andrisk to certain cancers that has been described among these two groups. Taking into accountthat North African populations have been scarcely described for these genes, and consideringthe rich genetic past of this region with a noticeable Sub-Saharan African contribution to theiroriginal background, it is interesting a revision and description of some relevantpolymorphisms (González-Pérez et al. 2010; Hen et al. 2012)

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