Caracterización de pacientes perinatalmente infectados por VIH-1 con un inicio precoz del tratamiento antirretroviral

  1. Domínguez Rodríguez, Sara
Dirigée par:
  1. Pablo Rojo Conejo Directeur
  2. Alfredo Tagarro García Directeur/trice

Université de défendre: Universidad Complutense de Madrid

Fecha de defensa: 14 juillet 2021

Jury:
  1. J. T. Ramos Amador President
  2. Rafael Rubio García Secrétaire
  3. Santiago Moreno Guillén Rapporteur
  4. Denise Naniche Rapporteur
  5. José Alcamí Pertejo Rapporteur
Département:
  1. Salud Pública y Materno-Infantil

Type: Thèses

Résumé

Since the beginning of the epidemic, HIV mother-to-child transmission has been recognised as a major public health issue. Despite the great efforts done to reduce HIV infection among children, in 2015, more than 150,000 children became infected with HIV. Early combination antiretroviral therapy (ART) initiation in vertically infected infants with HIV has had a major impact on clinical outcomes reducing morbidity and mortality. Moreover, early initiation of ART leads to a significantly smaller reservoir size and a better immune reconstitution. However, definitions of early vary a great deal and literature reporting on ART initiation in the first year of life rarely reports on outcomes when treatment is initiated in the neonatal period. Also, there is limited information about factors associated with the rapid decline of the viral load in infants...