Análisis del nicho vascular e identificación de nuevos patrones de señalización molecular en anafilaxia

Resumo

Anaphylaxis is the most severe systemic hypersensitivity reaction that occurs suddenly and can cause death. Anaphylaxis reactions affect different organs and/or systems and there is a wide range of signs and symptoms manifested by these patients. Hypotension and hypoxia are key factors contributing to the severity of episodes by causing homeostatic imbalance. Vaso- and broncho-constriction occurring in the thoracic cavity, loss of peripheral vascular resistance and increased vascular extravasation accompany most severe reactions. Molecular mechanisms described in the pathophysiology of anaphylaxis point to the action of mediators released by effector immune cells as the cause of these effects. Given that the involvement of the vascular system is crucial in the development of anaphylaxis and that the treatment of choice in clinical practice is adrenaline, the main objective of this thesis is to investigate the pathophysiology of the vascular niche in human anaphylaxis and to identify new molecular signalling patterns...